ESCI Council: Gemma Vilahur, Luca Liberale
Invited Organizer(s): Sofia Pereira, Joao Pedro Ferreira
Meeting room: 

Wednesday, 3 June 

13:30 – 15:00 Joint Session ESC WG Thrombosis, WG on Atherosclerosis and Vascular Biology and WG on Coronary Pathophysiology and Microcirculation and ESCI
Chair: Gemma Vilahur (Spain)
Chair: Luca Liberale (Italy)

13:30-13:45 15’ (10+5)      Artificial Intelligence and the Future of Cardiovascular Medicine Thomas Lüscher (UK)      

13:45-14:00 15’ (10+5)      Changing clinical perspectives on sex and healthcare disparities in ischemic heart disease Edina Cenko (Italy)

14:00-14:15 15’ (10+5)      Predictive models in medicine and science Simon Kraler (Switzerland)

14:15-14:30 15’ (10+5)      High-Density Lipoproteins: More Than a Cholesterol Carrier in Cardiovascular Risk Teresa Padro (Barcelona, Spain)

14:30-14:45 15’ (10+5)      Vascular effects of GLP-1 and other incretin mimetics Elena Osto (Austria)

14:45-15:00 15’                  Adverse HDL remodelling links type 2 diabetes mellitus to subclinical high-risk coronary plaque burden Gabriela Giron

Coffee-break

15:30 – 17:00 Session 2 Molecular and Translational Insights in Cardiometabolic Disease 
Chair: Federico Carbone (Italy)
Chair: Sofia de Azeredo Pereira (Portugal)  

15:30–15:50 20’ (15+5)     Sulphonomics in cardiovascular disease Natália Marto (Portugal)

15:50-16:10 20’ (15+5)      Renin-aldosterone dysregulation across CKM conditions João Pedro Ferreira (Portugal)

16:10-16:30 20’ (15+5)     Functional Characterization of LDLR Variants Towards Personalized Medicine Mafalda Bourbon (Portugal)

16:30-16:45 15’                 Metagenomic profiling of Kidney Stone Microbiota reveals diversity across stone compositions in a pilot cohort Antonio Melo Junior

16:45-17:00 15’                 Eicosapentaenoic acid ethyl restores metabolic resilience in hypertriglyceridemic rats subjected to acute myocardial infarction Sebastian Alcover

17.00-17.30   Opening ceremony

17.30-18.30   Opening lecture

18.30            Welcome drink


Thursday, 4 June

08.30-10.00 Session 3 Joint session EU-METAHEART COST ACTION – ESCI                                             
Chair: Simon Kraler (Switzerland) 
Chair: Lina Badimon (Spain)

08:30-08:50 20’ (15+5)     The Spleen: A Key Player in Cardiovascular Signaling Petra Kleinbongard (Germany)

08:50-09:10 20’ (15+5)     JCAD: From bench to bedside Luca Liberale (Italy)

09:10-09:30 20’ (15+5)     From bone marrow to myocardium:health matters in post-myocardium infarction repair Gemma Vilahur (Spain

09:30-09:45 15’                 Restoring HDL cardioprotection: ApoM-enriched HDL-mimetic nanoparticles limit cardiac damage and improve heart function after myocardial infarction in ApoE-/-                                               mice Lisaidy Ramos

09:45-10:00 15’                 The role of Interleukin-6 as a central mediator of cardiac and vascular dysfunction in Cancer associated cachexia Ana Isabel Antunes            

10.00-11.00   Coffee-break & Poster Session (Group A)

11:00 – 12:30 Session 4 Joint session: ESC- ESCI
Chairs: Luca Liberale (Italy) 
Chairs: Gemma Vilahur (Spain)

11:00-11:20 20’ (15+5)      Targeting Mitochondrial Plasticity in Cardiometabolic Disorders Danilo Norata (Italy)

11:20-11:40 20’ (15+5)      Inflammation in Atherosclerosis and Cardiovascular Disease: The Long Path from Biology to Clinical Practice Lina Badimon (Spain)

11:40-12:00 20’ (15+5)      What is new in antithrombotic therapy? José Luís Ferreiro (Spain)

12:00-12:15 15’                 Circulating extracellular vesicles associate with cardiovascular resilience in familial hypercholesterolemia Aitana Casanova

12:15-12:30 15’                 Inflammatory HDL Proteomic Signatures in Familial Hypercholesterolemia: Insights into Cardiovascular Event Resilience Paula Cabré

12.30-13.30   Lunch & Poster Session (Group B)

14:30 – 16:00 Session 5 Advances in Cardiorenal and Cardiovascular Disease 
Chair: Aldo Bonaventura (Italy)
Chair: Flávio Reis (Portugal) 

14:30-14:45 15’ (10+5)      AhR in CKM Axis of Obstructive Sleep Apnea Sofia Azeredo Pereira (Lisbon, Portugal)

14:45-15:00 15’ (10+5)      Peritoneal membrane fibrosis as a window to the vulnerability of  the cardiovascular system Patrícia Branco (Lisbon, Portugal)

15:00-15:15   15’ (10+5)    Use of iPSC-derived cardioids to model human cardiac function and disease José Belo (Lisbon, Portugal)

15:15-15:30 15’                 Cardioprotection with intravenous-atorvastatin is associated with reduced acute brain alterations: dose-finding studies in a porcine model of myocardial infarction Sergi Otero

15:30-15:45 15’                 A patient-derived cell approach to explore peritoneal membrane alterations associated with AhR signaling Diogo Sequeira

16.00-16.50 Round table: Cardiovascular and Immune Mechanisms in Women Across the Lifespan

16.30-17.30   Brief oral sessions and coffee-break

17.30-18.30   Satellite Symposium: Pas Gras

19.30             Congress dinner

Friday, 5 June

09.00-10.30  Session 6 Novel Pathways and Clinical Challenges in Cardiovascular and Renal Disease 
Chair: Simon Kraler (Switzerland)
Chair: Petra Kleinbongard (Germany) 

09:00-09:20 20’ (15+5)      Pleiotropic cardiovascular effects of GLP-1 mimetic drugs Stefano Ministrini (Italy)

09:20-09:40 15’ (15+5)      From Risk Factors to Risk Ecosystems: AI and the New Cardiometabolic Medicine Federico Carbone (Italy)

09:40-10:00 15’ (15+5)      Tricuspid regurgitation: the “forgotten valve” that is suddenly a big deal Carlos Zaragoza (Spain)

10:00-10:15 15’                  Altered peroxidasin expression pattern in IgA nephropathy Isabel Brandao

10:15-10:30 15’                  Cholesteryl Hemiglutarate–Induced Lysosomal Hyperacidification Drives Iron-Dependent Mitochondrial Dysfunction in Atherosclerosis Otília Vieira

10.30-11.30   Coffee-break & Poster Session (Group C)

11.30-13.00 Session 7 New Perspectives in Cardiorenal Disease and Heart Failure 
Chair: Carlos Zaragoza (Spain)
Chari: Patrícia Branco (Portugal) pqbranco@ulslo.min-saude.pt

 11:30-11:45 15’ (10+5)     Progress Toward Reducing the Need for Dialysis Among Young Individuals with Type 1 Diabetes Aníbal Ferreira (Portugal)

11:45-12:00 15’ (10+5)      GLP-1 Receptor Agonists in Heart Failure Joao Sergio Neves (Portugal)

12:00-12:15 15’ (10+5)      MicroRNAs in CKD-CVD Crosstalk Ines Alencastre (Portugal)

12:15-12:30 15’                  Cardiovascular health in the netherlands based on the life’s essential 8 Lieke Steendam

12:30-12:45 15’                 Thiol signatures during peritoneal equilibration testing and their association with membrane-protective candidate drugs in peritoneal dialysis Sofia Anao

13.00-14.00 Lunch & Poster Session (Group D)

14:00-14:30 European Journal Clinical Investigation

14:30-15:30 ESCI Awards

15:30-16:30 Albert Struyvenberg Medal

16:30-17:00 Closing ceremony