Symposium 3 | Metabolic Crossroads: Lipids, Liver Function, and Microbiota Interactions
ESCI Council: Paula Macedo and Marcin Krawczyk
ESCI YRC: Harshitha Shanmugam
Invited Organizer(s): Federico Gatto, Edoardo Giannini, and Piero Portincasa
Meeting room: Salone dei Dogi (Castello Boccanegra)
12.30-13.30 Satellite symposium
13.00-13.30 ESCI Members meeting
13.30-15.00 Session 3.1. Lipid Dysfunction in Metabolic Disorders
Chairs: Marcin Krawczyk, Paula Macedo
13.30-13.50 Adipose Tissue Dysfunction: A Central Driver of MASLD, by Amalia Gastaldelli (Pisa, Italy)
13.50-14.10 Clinical Presentation of LAL-Deficiency, a Rare Dislipidemia with Liver Involvement, by Livia Pisciotta (Genoa, Italy)
14.10-14.30 Statins and nonalcoholic fatty liver disease in the era of precision medicine, by Fabio Nascimbeni (Modena, Italy)
14.30-14.45 Oral presentation (abstract 115): Comparison of free fatty acid lipotoxicity in HepG2/C3A cells with superactivated
and inhibited autophagy, by B. Pakula (Warsaw, Poland)
14.45-15.00 Oral presentation (abstract 107): The relationship between TyG and AIP indices and insulin resistance and adipose tissue dysfunction
in individuals with Obesity without Diabetes, by C. Magalhães (Coimbra, Portugal)
15.00-15.30 Coffee-break
15.30-17.00 Session 3.2. Microbiota-Liver Interactions in Metabolic Health
Chairs: Federico Gatto, Edoardo Giannini
15.30-16.00 Microbiome Changes and Syndrome of Bacterial Overgrowth in Patients
with Dyslipidemia, by Khrystyna Kvit (Lviv, Ukraine)
16.00-16.30 Probiotic Lactobacillus rhamnosus Mitigates Ductular Reaction in Mcpip1-Deficient Mice
via Modulation of Gut-Liver Crosstalk, by Jerzy Kotlinowski (Krakow, Poland)
16.30-16.45 Oral presentation (abstract 74): Gestational Diabetes Alters Neonatal GGT: Links to Neonatal Metaflammation
and Metabolic Health
16.45-17.00 Oral presentation (abstract 181):
with OMNi-BiOTiC® METAtox Multistrain Probiotics: A 30-Day Intervention, by L. Mahdi (Bari, Italy)
17.00-17.30 Opening ceremony
17.30-18.30 Opening lecture
18.30 Welcome drink
09.00-10.30 Session 3.3. Complexities in Liver and Metabolic Disorders
Chairs: Piero Portincasa, Harshitha Shanmugam
09.00-09.30 MetALD: Challenges of coexisting metabolic dysfunction and alcohol toxicity in the liver, by Gyorgy Baffy (Boston, USA)
09.30-10.00 Linking MASH to Chronic Kidney Disease, by Sonia Najjar (Ohio, USA)
10.00-10.15 Oral presentation (abstract 109): Carotid Sinus Nerve Resection: A key to improve liver function
in metabolic disease, by J. Sacramento (Lisboa, Portugal)
10.15-10.30 Oral presentation (abstract 207):
and its link to liver disease, by L. Herrera (lisboa, Portugal)
10.30-11.00 Coffee-break
11.00-12.30 Session 3.4. Gut-Liver Axis and Therapeutics
Chairs: Jerzy Kotlinowski, Michał Żorniak
11.00-11.30 Next Generation Probiotics and MASLD, by Giovanni Sarnelli (Napoli, Italy)
11.30-12.00 Genetic Profiling for Carbohydrate Maldigestion in Irritable Bowel Syndrome, by Mauro D’Amato (Bari, Italy)
12.00-12.15 Oral presentation (abstract 63): Differential effects of bariatric surgery on circulating GDF15 and FGF21 levels: implications
for glycemic status and weight loss outcomes, by L. Salmón-Gómez (Pamplona, Spain)
12.15-12.30 Oral presentation (abstract 187): P
An Ex Vivo Studies, by V. Perniola (Bari, Italy)
12.30-13.30 Poster session
13.00-14.00 Satellite symposium
13.30-14.30 Lunch
14.30-16.00 Session 3.5. Hormonal and Lifestyle Modulators in Obesity and Liver Health
Chairs: Mauro D’Amato, Diego Ferone
14.30-15.00 Hormonal, Metabolic, and Gastrointestinal Motility Changes in Subjects
with Obesity Undergoing Sleeve Gastrectomy, by Gabriella Garruti (Bari, Italy)
15.00-15.30 Navigating the Metabolic Crossroads: Personalized Lifestyle Insights from EU Projects
on Obesity and Subclinical Liver Function, by Harshitha Shanmugam and Mohamad Khalil (Italy)
15.30-15.45 Oral presentation (abstract 173): Effect of weight loss on fat accumulation and liver microsomal function in patients
with Metabolic dysfunction Associated Steatotic Liver Disease (MASLD), by J. Johnbritto (Bari, Italy)
15.45-16.00 Oral presentation (abstract 105):
Dysfunction, by D. Sousa (Coimbra, Portugal)
16.00-17.00 Satellite symposium
17.00-18.00 Satellite symposium
20.00 Congress dinner
08.00-09.00 Satellite symposium
09.00-10.30 Session 3.6. Lipid Regulation and Energy Balance
Chairs: Silvia Vilares Conde, Luca Miele
09.00-09.30 Pancreatic Steatosis: The Fatty Time Bomb Fueling Diabetes or More?, by Michał Żorniak (Gliwice, Poland)
09.30-10.00 A new framework of obesity and the role of exposome, by Sara Becerril (Pamplona, Spain)
10.00-10.15 Oral presentation (abstract 52): Comparison of the effect of carotid body activity modulation vs. dietary approach on metabolic
control and impact on microbiota, by F. Martins (Lisbon, Portugal)
10.15-10.30 Oral presentation (abstract 143):
human hepatic metabolic fluxes, by J. Silva (Coimbra, Portugal)
10.30-11.00 Coffee-break
11.00-12.30 Session 3.7. Personalized Approaches and Sex-Specific Insights
Chairs: Gabriella Garutti, Livia Pisciotta
11.00-11.30 Sex Matters in Obesity and Longevity: Unveiling Metabolic Disparities, by Maria Paula Macedo (Lisbon, Portugal)
11.30-12.00 MASLD Therapies on the Horizon: Shaping the Future of Liver Disease Management, by Luca Miele (Rome, Italy)
12.00-12.15 Oral presentation (abstract 200): Enhancing the 5y-AdDiaRem Score: The Role of the Triglyceride-Glucose Index in Predicting
Long-Term Diabetes Remission After Bariatric Surgery, by A. Scuricini (Genoa, Portugal)
12.15-12.30 Oral presentation (abstract 225):
with Cirrhosis, by A. Pasta (Genoa, Portugal)
13.00-14.00 Satellite symposium
14.00-17.00 Closing lectures and session | ESCI Awards Ceremony 2025
