Symposium 1 | Mitochondria: physiology and pathology
ESCI Council: Mariusz Wieckowski and Paulo Oliveira
ESCI YRC: Felippe Zuccolotto Dos Reis, Stefano Ministrini
Invited Organizer(s): Michelangelo Campanella
Meeting room: Room Santa Caterina (Castello Boccanegra)
Wednesday, 21 May
13.00-13.30 ESCI Members meeting
13.30-15.00 Session 1.1. Mitochondrial signalling in health and disease - part I
Chairs: Paulo Oliveira (Coimbra, Portugal), Mariusz Wieckowski (Warsaw, Poland)
13.30-14.00 The mitochondrial sites of contact with the nucleus: form and function, by Michelangelo Campanella (London, UK)
14.00-14.30 Expanding the molecular signatures of mitochondrial genetic disease:
the role of emerging technologies, by Robert Taylor (Newcastle, UK)
14.30-14.45 Oral presentation (abstract 220): Insights into Cellular Signaling and Metabolic Dysfunctions Involving
Mitochondrial-ER Contact Sites in a Rare Neurodevelopmental PACS2 Syndrome, by M. Lebiedzinska Arciszewska (Warsaw, Poland).
14.45-14.55 Flash talks from the posters (abstract 206):
15.00-15.30 Coffee-break
15.30-17.00 Session 1.2. Mitochondrial signalling in health & disease - part II
Chairs: Robert Taylor (Newcastle, UK), Afshan Malik (London, UK)
15.30-16.00 Mapping MCU-dependent protein networks and tissues and diseases, by Fabiana Perocchi (Munich, Germany)
16.00-16.30 Exploring the role of CLPB in mitochondrial Ca 2+ regulation and disease, by Denis Vecellio (Padua, Italy)
16.30-16.45 Oral presentation (abstract 12): Spermidine-induced Mitophagy as a Potential Modulator of Mitochondrial
Heteroplasmy in m.3243A>G Fibroblasts, by D. Li (Oxford, UK)
16.45-16.55 Flash talks from the posters (abstracts 86 and 114)
17.00-17.30 Opening ceremony
17.30-18.30 Opening lecture
18.30 Welcome drink
Thursday, 22 May
09.00-10.30 Session 1.3. Mitochondria in obesity and metabolic syndrome - part I (Joint with Pas Gras)
Chairs: Michelangelo Campanella (london, UK), María Eugenia Soriano (Padua, Italy)
09.00-09.30 The PAS GRAS project - an update, by Paulo J. Oliveira (Coimbra, Portugal)
09.30-10.00 Identifying pathways of mitochondrial dysfunction that may contribute to obesity
related co-morbidities, by Afshan Malik (London, UK)
10.00-10.15 Oral presentation (abstract 231): Knowledge and guidance rooted on interdisciplinary research and participatory
health promotion to tackling obesity in youth: the PAS GRAS Campaign, by A. Azul (Coimbra, Portugal)
10.15-10.25 Flash talks from the posters (abstracts 7 and 140)
10.30-11.00 Coffee-break
11.00-12.30 Session 1.4. Mitochondria in obesity and metabolic syndrome - part II (Joint with Pas Gras)
Chairs: Felippe Zuccolotto Dos Reis (Faro, Portugal), Silvia Ravera (Genoa, Italy)
11.00-11.30 Impact of metabolic status on bioenergetics in children and adults with obesity, by Eugénia Carvalho (Coimbra, Portugal)
11.30-12.00 Platelets' mitochondria in metabolic disease, by Hans Zischka (Munich, Germany)
12.00-12.15 Oral presentation (abstract 77): Unraveling the role of liver mechanotransduction and (mitochondrial) metabolism
in MASLD progression, by H. Gerardo (Coimbra, Portugal)
12.15-12.25 Flash talks from the posters (abstracts 142 and 179)
12.30-13.30 Poster session
13.00-14.00 Satellite symposium
13.30-14.30 Lunch
14.30-16.00 Session 1.5. Interaction between nuclear and mitochondrial genome
Chair: Hans Zischka (Munich, Germany), Eugénia Carvalho (Coimbra, Portugal)
14.30-15.00 ATAD3 Protein Family Members Orchestrate Mitochondrial Translation
with Metabolic Reprogramming, by Maria Eugenia Soriano (Padua, Italy)
15.00-15.30 PACS2 syndrome - looking for solutions for this ultra-rare disease through basic research, by Mariusz Wieckowski (Warsaw, Poland)
15.30-15.45 Oral presentation (abstract 177): Regulation of mitochondrial metabolism by IL12-family cytokines in chronic lymphocytic
leukemia: a novel perspective on therapeutic resistance, by N. Bertola (Genoa, Italy)
15.45-15.55 Flash talks from the posters (abstracts 172 and 201)
16.00-17.00 Satellite symposium
17.00-18.00 Satellite symposium
17.00-18.00 Poster session and coffee-break
20.00 Congress dinner
Friday, 23 May
08.00-09.00 Satellite symposium
09.00-10.30 Session 1.6. Mitochondria in age-related diseases - part I
Chairs: Stefano Ministrini (Zurich, Switzerland), Michele Visentin (Zurich, Switzerland)
09.00-09.30 Mitochondria transfer in glioblastoma, by Marie-Luce Vignais (Montpellier, France)
09.30-10.00 Synaptic transmission is abnormal in Ndufs4-/- mouse brain and human glutamatergic
neurons with NDUFS4 mutations, by Werner Koopman (Wageningen, The Netherlands)
10.00-10.15 Oral presentation (abstract 211): Oxidative stress-driven degeneration of retinal pigment epithelium: role of photoreceptor
outer segments, by I. Panfoli (Genoa, Italy)
10.15-10.25 Flash talks from the posters (abstract 203)
10.30-11.00 Coffee-break
11.00-12.30 Session 1.7. Mitochondria in age-related diseases - part II
Chairs: Marie-Luce Vignais (Montpellier, France), Werner Koopman (Wageningen, The Netherlands)
11.00-11.30 The sweetest thing: the role of glucose and anaerobic glycolysis in drug-induced
mitochondrial toxicity, by Michele Visentin (Zurich, Switzerland)
11.30-12.00 Mitochondria and the heart, by Felippe Zuccolotto Dos Reis (Faro, Portugal)
12.00-12.15 Oral presentation (abstract 133): Aging-Related Oxidative and Endocrine Dysregulation in Liver, Adipose Tissue,
and Heart Influence Cardiometabolic Health, by L. Grilo (Coimbra, Portugal)
12.15-12.25 Flash talks from the posters (abstract 29)
12.30-14.00 Poster session and lunch
13.00-14.00 Satellite symposium
14.00-17.00 Closing lectures and session | ESCI Awards Ceremony 2025
ESCI YRC: Felippe Zuccolotto Dos Reis, Stefano Ministrini
Invited Organizer(s): Michelangelo Campanella
Meeting room: Room Santa Caterina (Castello Boccanegra)
Wednesday, 21 May
13.00-13.30 ESCI Members meeting
13.30-15.00 Session 1.1. Mitochondrial signalling in health and disease - part I
Chairs: Paulo Oliveira (Coimbra, Portugal), Mariusz Wieckowski (Warsaw, Poland)
13.30-14.00 The mitochondrial sites of contact with the nucleus: form and function, by Michelangelo Campanella (London, UK)
14.00-14.30 Expanding the molecular signatures of mitochondrial genetic disease:
the role of emerging technologies, by Robert Taylor (Newcastle, UK)
14.30-14.45 Oral presentation (abstract 220): Insights into Cellular Signaling and Metabolic Dysfunctions Involving
Mitochondrial-ER Contact Sites in a Rare Neurodevelopmental PACS2 Syndrome, by M. Lebiedzinska Arciszewska (Warsaw, Poland).
14.45-14.55 Flash talks from the posters (abstract 206):
15.00-15.30 Coffee-break
15.30-17.00 Session 1.2. Mitochondrial signalling in health & disease - part II
Chairs: Robert Taylor (Newcastle, UK), Afshan Malik (London, UK)
15.30-16.00 Mapping MCU-dependent protein networks and tissues and diseases, by Fabiana Perocchi (Munich, Germany)
16.00-16.30 Exploring the role of CLPB in mitochondrial Ca 2+ regulation and disease, by Denis Vecellio (Padua, Italy)
16.30-16.45 Oral presentation (abstract 12): Spermidine-induced Mitophagy as a Potential Modulator of Mitochondrial
Heteroplasmy in m.3243A>G Fibroblasts, by D. Li (Oxford, UK)
16.45-16.55 Flash talks from the posters (abstracts 86 and 114)
17.00-17.30 Opening ceremony
17.30-18.30 Opening lecture
18.30 Welcome drink
Thursday, 22 May
09.00-10.30 Session 1.3. Mitochondria in obesity and metabolic syndrome - part I (Joint with Pas Gras)
Chairs: Michelangelo Campanella (london, UK), María Eugenia Soriano (Padua, Italy)
09.00-09.30 The PAS GRAS project - an update, by Paulo J. Oliveira (Coimbra, Portugal)
09.30-10.00 Identifying pathways of mitochondrial dysfunction that may contribute to obesity
related co-morbidities, by Afshan Malik (London, UK)
10.00-10.15 Oral presentation (abstract 231): Knowledge and guidance rooted on interdisciplinary research and participatory
health promotion to tackling obesity in youth: the PAS GRAS Campaign, by A. Azul (Coimbra, Portugal)
10.15-10.25 Flash talks from the posters (abstracts 7 and 140)
10.30-11.00 Coffee-break
11.00-12.30 Session 1.4. Mitochondria in obesity and metabolic syndrome - part II (Joint with Pas Gras)
Chairs: Felippe Zuccolotto Dos Reis (Faro, Portugal), Silvia Ravera (Genoa, Italy)
11.00-11.30 Impact of metabolic status on bioenergetics in children and adults with obesity, by Eugénia Carvalho (Coimbra, Portugal)
11.30-12.00 Platelets' mitochondria in metabolic disease, by Hans Zischka (Munich, Germany)
12.00-12.15 Oral presentation (abstract 77): Unraveling the role of liver mechanotransduction and (mitochondrial) metabolism
in MASLD progression, by H. Gerardo (Coimbra, Portugal)
12.15-12.25 Flash talks from the posters (abstracts 142 and 179)
12.30-13.30 Poster session
13.00-14.00 Satellite symposium
13.30-14.30 Lunch
14.30-16.00 Session 1.5. Interaction between nuclear and mitochondrial genome
Chair: Hans Zischka (Munich, Germany), Eugénia Carvalho (Coimbra, Portugal)
14.30-15.00 ATAD3 Protein Family Members Orchestrate Mitochondrial Translation
with Metabolic Reprogramming, by Maria Eugenia Soriano (Padua, Italy)
15.00-15.30 PACS2 syndrome - looking for solutions for this ultra-rare disease through basic research, by Mariusz Wieckowski (Warsaw, Poland)
15.30-15.45 Oral presentation (abstract 177): Regulation of mitochondrial metabolism by IL12-family cytokines in chronic lymphocytic
leukemia: a novel perspective on therapeutic resistance, by N. Bertola (Genoa, Italy)
15.45-15.55 Flash talks from the posters (abstracts 172 and 201)
16.00-17.00 Satellite symposium
17.00-18.00 Satellite symposium
17.00-18.00 Poster session and coffee-break
20.00 Congress dinner
Friday, 23 May
08.00-09.00 Satellite symposium
09.00-10.30 Session 1.6. Mitochondria in age-related diseases - part I
Chairs: Stefano Ministrini (Zurich, Switzerland), Michele Visentin (Zurich, Switzerland)
09.00-09.30 Mitochondria transfer in glioblastoma, by Marie-Luce Vignais (Montpellier, France)
09.30-10.00 Synaptic transmission is abnormal in Ndufs4-/- mouse brain and human glutamatergic
neurons with NDUFS4 mutations, by Werner Koopman (Wageningen, The Netherlands)
10.00-10.15 Oral presentation (abstract 211): Oxidative stress-driven degeneration of retinal pigment epithelium: role of photoreceptor
outer segments, by I. Panfoli (Genoa, Italy)
10.15-10.25 Flash talks from the posters (abstract 203)
10.30-11.00 Coffee-break
11.00-12.30 Session 1.7. Mitochondria in age-related diseases - part II
Chairs: Marie-Luce Vignais (Montpellier, France), Werner Koopman (Wageningen, The Netherlands)
11.00-11.30 The sweetest thing: the role of glucose and anaerobic glycolysis in drug-induced
mitochondrial toxicity, by Michele Visentin (Zurich, Switzerland)
11.30-12.00 Mitochondria and the heart, by Felippe Zuccolotto Dos Reis (Faro, Portugal)
12.00-12.15 Oral presentation (abstract 133): Aging-Related Oxidative and Endocrine Dysregulation in Liver, Adipose Tissue,
and Heart Influence Cardiometabolic Health, by L. Grilo (Coimbra, Portugal)
12.15-12.25 Flash talks from the posters (abstract 29)
12.30-14.00 Poster session and lunch
13.00-14.00 Satellite symposium
14.00-17.00 Closing lectures and session | ESCI Awards Ceremony 2025
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