Posters and Happy Hour 1
| Thursday, June 18, 2026 |
| 16:00 - 18:00 |
Speaker
Dr. Anil Akturk
Professor
The Jackson Laboratory
Characterization of the TcMAC21 transchromosomic mouse model for Down Syndrome reveal compromised reproductive performance and premature lethality associated with kidney failure
Dr. Jonathan An
Assistant Professor
University Of Washington
Dp16 Mice Exhibit Accelerated Periodontal Bone Loss
Dr. Aaron Argall
Postdoctoral Scientist
Nationwide Children's Hospital
Trisomy 21 Alters Cardiac Differentiation Trajectories and Cardioid Morphogenesis in a DS+AVSD iPSC Model
Ms. Amilah Azam
MD Candidate
Baylor College Of Medicine
Placental Findings among Trisomy 21 Live-births and Fetal Demises
Ms. Heather Becker
Research Professional, Psychometrist
Linda Crnic Institute For Down Syndrome
Systematic Analysis of Language Transcripts (SALT)
Dr. Anita Bhattacharyya
Associate Professor
University of Wisconsin-Madison
Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
Ms. Marie-Anne CAILLAUD
Clinical Project Manager
Institut Jerome Lejeune
Generation and characterization of iPSC lines derived from monozygotic twin brothers discordant for trisomy 21 within the COLIBRI study (NCT05767216)
Ms. Marie-Anne CAILLAUD
Clinical Project Manager
Institut Jerome Lejeune
Early detection and treatment of obstructive sleep apnea in infants with Down syndrome: 36- and 60-months results
Ms. Maci Cameron
Clinical Coordinator
Linda Crnic Institute For Down Syndrome
Pathologically Elevated Serum and Cerebrospinal Fluid Anti-Glutamic Acid Decarboxylase 65 Antibodies in a Person with Down Syndrome Regression Disorder
Ms Natalie Baker Campbell
Phd Student
Boston University
Trisomy 21 Promotes Precocious Oligodendrocyte Maturation and Perturbs Neuron–Glia Communication in Human Forebrain Assembloids
Dr. Marie Channell
University of Illinois Urbana-Champaign
Latent profile analysis for phenotyping co-occurring autism profiles among youth with Down syndrome
Dr. Heidi Chial
Assistant Professor
University of Colorado Alzheimer's and Cognition Center, Dept. Neurology, Linda Crnic Institute for Down Syndrome
Targeting Trisomy 21 Mosaicism Caused by Mitotic Spindle Defects and Chromosome Mis-segregation as a Novel Approach to Drug Discovery in Alzheimer’s Disease and Related Dementias
PhD Student Laury Dancette
PhD Student
Paris Brain Institute
Role of Martinotti inhibitory interneurons on cognitive deficits in Down syndrome and their modulation via α5-containing GABAA receptors.
Dr. Utpal Das
Associate Scientist
University of California San Diego
Aβ Induces Endolysosomal Dysfunction via Rab GTPase Activation and Membrane Disruption
Senhor. José Welmer De Araújo Carvalho
Presenting Author
Universidade Federal De São Paulo
Physical Activity Is Associated with a Favorable Inflammatory Profile in Individuals with Down Syndrome
Dr. Ranga Dissanayake
Research Service Senior Prof
Linda Crnic Institute Of Down Syndrome
COMPARATIVE ANALYSIS OF BONE MARROW AND SKIN ORGANOIDS DERIVED FROM TRISOMY 21 AND DISOMY 21 PATIENT-SPECIFIC iPSCs
Dr. Micah Donovan
Instructor, Phd
Linda Crnic Institute for Down Syndrome
Adaptive Immune Dysregulation in Down Syndrome Revealed by Autoantibody Profiling and B-Cell Receptor Repertoire Analysis
Dr. Jeremias Dutto
Post Doc
UNC-CONICET
Immune dysregulation in children with Down Syndrome: Single-cell multi-omics reveal Th1-Skewed CD4⁺ differentiation, reduced mature Tfh, and altered tonsillar architecture
Dr. Henric Ek Olofsson
Postdoctoral fellow
University Of Colorado Anschutz Medical Campus
Neuroinflammatory pathways across the life span of individuals with Down syndrome
Dr. Victoria Fleming-Batayneh
Research Associate
University Of Wisconsin - Madison
Association of inflammation with obesity, aging, and amyloid burden in adults with Down syndrome
Dr. Dea Garic
Assistant Professor
University Of North Carolina At Chapel Hill
Subcortical Brain Development in Infants with Down Syndrome from 6 to 12 months of age
Dr. Lucas Gillenwater
Postdoctoral Fellow
University Of Colorado | Anschutz Medical Campus
Dissecting gene expression variation across multimorbidity profiles in people with Down syndrome
Ms. Rebecca Gomez
Research Technician
Benaroya Research Institute
Integrated analysis of cellular and antibody response to SARS-CoV-2 vaccination in people with Down syndrome reveals the role of immune aging
Dr. Dongxu Guan
Electrophysiologist
University Of California San Diego
Abnormal Intrinsic Excitability and Synaptic Transmission of Hippocampal CA1 Pyramidal Neurons in Ex Vivo Brain Slices from Down Syndrome Mouse Models of Dp(16)1Yey/+ and TcMAC21
Dr. Eric Hamlett
Assistant Professor
Medical University of South Carolina
Comparison of existing scRNASeq datasets to elucidate artheroma-free transcriptional signatures of Down syndrome
Md/phd Student Hayden Hawks
Neuroscience Graduate Student
University Of Kansas Medical Center
Developmental origins of aberrant neurological trajectories in Down syndrome
Mr. Ty Hergenreder
Lab Technician
University Of Michigan
A consistent role of Dscam in GABAergic synaptogenesis across brain regions and mouse models of Down syndrome
Ms. Paula Hernandez
Undergraduate Researcher
The University Of Texas At Austin
Identifying Hsa21 Genes That Phenocopy Autism-Associated Mutations in C. elegans
Dr. Antony Hoarau
Postdoc
The Lundquist Institute
Upregulated IFN signaling in developing Trisomy 21 Lungs alters Angiogenesis
Dr. Mingxia Huang
Associate Professor
University Of Colorado
Synergistic effects of mild traumatic brain injury and trisomy 21: revealing latent vulnerabilities in the Dp16 mouse model
Ms. Swetha Iyer
Graduate Student
University of Texas at Austin
Genes have expression ceilings that predict overexpression sensitivity
Dr. Jeffrey Jacot
Associate Professor Of Bioengineering
University Of Colorado Anschutz
Endocardial Differentiation of iPSC from Down Syndrome to Investigate Congenital Heart Defects
Dr. Natalia Jaeger
Research Associate
Linda Crnic Institute For Down Syndrome
Correlates of B cell Lymphopenia in Down Syndrome
Ms. Harpreet Kaur
Ph.D. Candidate
Texas A&M University, College Station, TX
Mitochondrial Dysfunction, Impaired Mitophagy and DNA Damage Leads to STING-mediated Inflammation in Dp16 Liver & Skeletal Muscle
Dr. Bridgette Kelleher
Associate Professor
Purdue University
Caregiver Perspectives on PANDABox: Qualitative Feedback to Inform Telehealth Assessment Optimization in Down Syndrome
Dr. Leah Klein Borden
Postdoctoral Fellow
Massachusetts Institute of Technology
Investigating the Role of Extracellular Matrix in Down Syndrome Associated Cardiac Phenotypes
Dr. Cecilia Sze Lai Lai
Daphne Jackson Research Fellow
Queen Mary University Of London
Effect of Common Genetic Variations on Body Mass Index in Individuals with Down Syndrome
Dr Eva Lana-Elola
Principal Laboratory Research Scientist
Francis Crick Institute, UK
Comprehensive genetic mapping of a broad range of Down syndrome phenotypes
Mr. Eric Larsen
Graduate Student
University of Massachusetts Chan Medical School
Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B
Dr. Maria Lioudyno
Researcher
University Of California Irvine
The role of IFRD1 (Interferon-Related Developmental Regulator 1), in Alzheimer’s disease-like pathogenesis in cortical cell cultures with trisomy-21
Dr. Emma Loeffler
Postdoctoral Fellow
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Altered FGF pathway components in the developing lungs of individuals with Down Syndrome
Dr. Deirdre Logsdon
Postdoctoral Fellow
University of Colorado at Boulder
Modeling Early Placental Dysfunction in Down Syndrome with Human iPS Cells
Mr. Michael Ludwig
Sr. Professional
Linda Crnic Institute
Trisomy 21 Disrupts Canonical Regulation of Transient Site Specific Copy Gains
Ms. Hannah L. Mager
Graduate Student
National Institute Of Mental Health
Generation and Genomic Characterization of iPSC Lines from Individuals with Down Syndrome with and without Regression Disorder
Ms. Diane Martet
Institut Jérôme Lejeune
How does BMI affect adaptive behavior? A Go-DS21 ancillary study on people with Down Syndrome.
Ms. Eilis McLaughlin
Graduate Student
Purdue University
Sensory Experiences Relate to Naturalistic Social Engagement in Children with Neurogenetic Syndromes
Dr. Ivan Moskowitz
The University of Chicago
FOXF1 links failed Hedgehog signaling-dependent heterochronic control of developmental timing to birth defects in Down Syndrome
Mr. Juan Luis Musoles Lleó
Phd Student
Crg
Social stress exacerbates metabolic dysfunction and body weight gain in a Down syndrome mouse model
Mr. Christopher Ozeroff
Phd Candidate
Crnic Institue Boulder Branch, CU Boulder
Attribute Rank Enrichment Algorithm (AREA) Reveals Inflammatory Signaling Pathways Associated with Obesity in Down Syndrome
PhD Daniel Paredes
University of Denver / Knoebel Institute
Polyamine Dysregulation: A Mechanistic Link Between Down Syndrome and Cerebrovascular Disease
Mr. Mir Abbas Raza
Phd Candidate
University Of Dayton
Defining cerebellar circuit dysfunction underlying locomotor deficits in the Ts65Dn mouse model of Down syndrome
Dr. Laura Reiche
Postdoc
Dept. of Neurology, Bern University Hospital-Inselspital, University of Bern
Overexpression of C21ORF91 leads to glial cell misbalance and aberrant cell phenotypes in Down syndrome, which can be rescued by myelin repair drugs
Dr. Randall Roper
Professor
Indiana University Indianapolis
Sex-specific developmental phenotypes and their response to neonatal Dyrk1a reduction in the Ts65Dn Down syndrome mouse model
Mr. Justin Peter Rosales
Medical Student
TouroCOM
Unraveling the Nexus between Mitochondrial DNA and Mitochondrial Dysfunction in the Down Syndrome Cerebellum
Dr. Esteban Rozen
Crnic Institute Boulder Branch, Biofrontiers Institute, University Of Colorado Boulder
Hsa21-encoded Protein aRginine Methyl-Transferase 2 is an emerging druggable target in Trisomy 21.
Dr. Jonathan Santoro
Director of Neuroimmunology
Children's Hospital Los Angeles and the Keck School of Medicine of the University of Southern California
Developing a Screening Tool for Down Syndrome Regression Disorder: Navigating the Challenges of Rare Disease Recognition in the UK
Dr M Micaela Sartoretti
The Francis Crick Institute
Single-nucleus transcriptomic analysis reveals cellular and molecular alterations in the Down syndrome hippocampus
Ms. Marie Shi
MD-PhD Student
Boston University
Modeling Aberrant GABAergic Signaling in Down Syndrome with Human Dorsal Cortical Organoids
Ms. Rujuta Shinde
Bioinformatician
The Lundquist Institute
Single-Nucleus Transcriptomic Analyses Reveal Disrupted Epithelial Cell Adhesion Networks in Prenatal Trisomy 21 Lungs
Professor Peter Steyger
Director, Bellucci Translational Hearing Center
Creighton University, Omaha, NE)
Micro-CT Analysis of Middle and Inner Ear Architecture in a Down Syndrome Mouse
Mr. Alessandro Stillitano
Graduate Student
Rutgers University
Modeling Oligodendroglial Developmental Deficits in Down Syndrome Using human iPSC-derived Ventral Forebrain Organoids
Dr. Meaghan Sullivan
Postdoc
Cu Boulder
Variation in the IFN-ß response and its relationship to Down syndrome
Ms. Zenitha Sundararajan
Bioinformatics Analyst
Linda Crnic Institute
Holistic analysis of altered body mass index in Down syndrome
Dr Vivek Swarup
Associate Professor
University of California Irvine
Oligodendrocyte Remodeling Across Grey and White Matter in Down Syndrome–Associated and Sporadic Alzheimer’s Disease
Dr. Kaoru Takasaki
Assistant Professor Of Pediatrics
Children's Hospital Of Philadelphia
Single-cell atlas identifies transcriptional aberrances during Trisomy 21-related blood cell maturation
Dr. Celeste Tevis
Postdoctoral Fellow
Children's Hospital Colorado
Autism and Down Syndrome: Examining the Baby and Infant Screen for Autism Traits in Toddlers with Down Syndrome
Ms. Daniella Ugay
Phd Candidate
University Of Colorado Boulder
Defining the Molecular Basis of GATA1s Loss of Function
Mrs. Anne Vielle
Research Service Professional
University of Colorado
Trisomy 21 Disrupts Extracellular Vesicle Biogenesis and Cargo in a Human Cerebral Organoid Model
Dr. Celine K. Vuong
Project Scientist
University Of California, Los Angeles
A single-cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex
Dr. Kristy Welshhans
Assistant Professor
University Of South Carolina
Protein synthesis dynamics shaping Down syndrome neurobiology
Dr. Christopher William
Associate Professor of Pathology And Neurology
NYU School Of Medicine
Contribution of Dyrk1a trisomy to juvenile visual cortical plasticity impairment in Down syndrome model mice
Dr Elena Woods
Research Associate
University Of Colorado
Stroma disfunction in The Secondary Lymphoid Tissue as a Mechanism of Immune Dysregulation in Trisomy 21
Ms. Bruna Zampieri
Assistant Professor
University of São Paulo
Isolation And Characterization Of Plasma Astrocyte-derived Extracellular Vesicles In Down Syndrome
Dr. Erik Willis
Associate Research Scientist
University of North Carolina-Chapel Hill
Developing a Tailored Healthy Lifestyle Intervention for Families of Young Children with Down Syndrome
Dr. Lauren Dunn
Postdoctoral Fellow
Linda Crnic Institute For Down Syndrome
Altered Hepatic Metabolism in Down Syndrome
Mss. Zeynep Atak
Phd Candidate
Boston University
Dysregulated Calcium Dynamics in TcMAC21 Motor Cortex During Awake Locomotion
Ms. Maria Grisales
PhD Candidate
University Of Central Florida
Development of a Human IPSC-Based Neural Microphysiological System to Model Down Syndrome
Dr Jenny Klein
Postdoctoral Associate
The Broad Institute Of Mit And Harvard
Aberrant chromatin remodeling underlies human neural cell fate change in Trisomy 21
Dr Laura Xicota
Associate Research Scientist
Gertrude H Sergievsky Center, Columbia University Irving Medical Center
The G709S mutation in the APP gene protects against Alzheimer’s disease in Down syndrome.
Dr. lilia Gheghiani
Post Doc
Department of Pathology, Virginia Commonwealth University
Micronuclei Profiling of Isogenic Trisomic/Disomic Cells from People with Mosaic Down Syndrome Reveals a Trisomy 21- and Age-Associated Increase in Genome-wide Chromosomal Instability
Mr. Jacob Dohl
Graduate Student
University of California, Irvine
Examining the Calcineurin-NFAT Axis in the Pathology of Alzheimer Disease in the General Population and People with Down Syndrome
Prof. Marzia Perluigi
Professor
Sapienza University Of Rome
PROTEOME PROFILE OF ALZHEIMER-LIKE PHENOTYPES IN THE BRAIN OF YOUNG AND OLD INDIVIDUALS WITH DOWN SYNDROME: FOCUS ON BACH1/NRF2 AXIS
Dr Hannah Rea
Assistant Professor
West Virginia University
A pilot study on executive functioning and challenging behaviors in youth with Down syndrome
Dr Mattias F. LINDBERG
Researcher
Perha Pharmaceuticals
Targeting DYRK1A in Neurodegeneration: Mechanistic Insights into Leucettinib-21 Targets Using Chemical and Cellular Approaches
Ms. Elizabeth Kharitonova
Phd Student
Boston University
Cortical organoid model of Down syndrome shows disrupted neuronal signaling attributed to dysregulated inhibitory tone
Ms. Susan Ruskin
Research Technician
Benaroya Research Institute
Investigating the Mechanisms Behind Dysregulated SARS-CoV-2 Vaccine Responses in Individuals with Down Syndrome
Dr Kristian Schafernak
Phoenix Children's Hospital
Postnatal cerebellar alterations in glial development in Down syndrome
Dr. Marco Emili
Post-doctoral researcher
University of Bologna
Neonatal treatment with nanoparticle-delivered astaxanthin: effects on hippocampal development and brain oxidative stress in the Ts65Dn mouse model of Down syndrome
Dr. Carol Wilkinson
Assistant Professor
Boston Children's Hospital
Altered brain maturation in young children with Down Syndrome
Ms. Daphne Quang
Graduate Student
Cu Anschutz
Longitudinal in situ 3D imaging reveals Alzheimer’s neuropathologies and cell type-specific vulnerabilities in trisomy 21 microglia-containing cerebral organoids
Mr. Andrew Folz
Phd Student
Indiana University Indianapolis
Sex-specific cerebellar phenotypes in an adolescent genetic Dyrk1a normalization Down syndrome mouse model
Ms. Kaylyn Van Deusen
Graduate Student
Colorado State University
Investigation of biosignatures associated with neurodevelopment profiles of children with Down syndrome
Ms. Zaria Jackson
Phd Student
Cu Anschutz School Of Pharmacy And Pharmaceutical Sciences
NEURODIFFERENTIATION AND ACETYLATION OF SOD2 IN TRISOMY 21
Ms. Cristina Lau
Graduate Student
University Of Colorado Anschutz
Deciphering Central Nervous System Autoimmunity in Down Syndrome
Prof. Y. Eugene Yu
Professor
Roswell Park Cancer Institute
Duplication-based genetic dissection of the Down syndrome critical region reveals its complex functional organization
Miss Barbara Zulli
Phd Student
Sapienza University Of Rome
Brain Insulin Resistance as a Sex-independent Hallmark of Alzheimer’s disease risk in Down Syndrome
Dr. Carl Stafstrom
Professor
Johns Hopkins University
Increased Susceptibility to Infantile Spasms and Generalized Tonic-Clonic Seizures in a Down Syndrome Mouse Model Carrying Human Chromosome 21
Dr. Karen Rossmassler
Research Associate
Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
Integrated analysis reveals alterations of the tongue microbiome in Down syndrome
Ms. Alyssa Schuett
Research Assistant
Uw Madison
Role of Down Syndrome Cell Adhesion in Pancreatic Islet Morphology and Function
Dr. Pinku Halder
Postdoctoral Researcher
IGBMC
Obesity-associated alterations in iPSC-derived hypothalamic neurons in individuals with Down syndrome are linked to interferon pathway
Dr. Antonella Izzo
Researcher
University Of Naples Federico II
Allele-Specific CRISPR Editing to Dissect Gene Dosage–Dependent Neuronal Defects in Trisomy 21
Dr. Daniel Heller
Postdoctoral Researcher
University Of Virginia
Investigating How Perineuronal Nets and Interstitial Aggregan Matrix Alterations in Down Syndrome Mice Influence Intrinsic Neuronal Excitability and Plasticity
Dr. Ariel Timkovich
Postdoctoral Fellow
University of Colorado Anschutz
The Trisomy 21 Model Atlas
Dr. Keenan Kushner
Postdoctoral Fellow
University of Colorado at Boulder
A mouse model of Down syndrome, Ts66Yah, possess age-dependent sleep abnormalities and heightened neuroinflammation
Miss Chiara Sette
Phd Student In Biochemistry
Sapienza Università Di Roma
Hippocampal O-GlcNAcylation dynamics across age in Ts66Yah mice: implications for Down syndrome and future pharmacological strategies
Prof. Orestes Forlenza
Full Professor at the Department of Psychiatry, Faculty of Medicine University of Sao Paulo
Buriti-ds Network
Cognitive decline in Down syndrome is associated with markers of biological ageing
Dr Cristina Perez-Ternero
Lecturer in Cardiovascular Pharmacology
Queen Mary University of London
Impaired mitochondrial respiration in the gastrocnemius muscle of Down syndrome mice
Ms. Amara Ayoub
Children's National Hospital
Neural rosette development in a dorsal forebrain spheroid model of Down syndrome
Ms. Sarah Wolff
Phd Student
Texas A&M University
Sexually dimorphic bone regeneration outcomes in skeletally mature Dp16 Down syndrome mice
Dr. Sara Onnivello
Researcher
University Of Padova
Developmental profile and variability in visuo-spatial, language and communication, socio-emotional and motor competences in preschool age children with Down syndrome
Mrs. Elisa Rossi
Phd Student
University of Padua
Heterogeneity of executive function profiles in school-age children and adolescents with Down syndrome
Dr. Nirinjini Naidoo
Professor
University of Pennsylvania
Early 4-Phenylbutyrate Intervention Ameliorates Cognitive Deficits in Down Syndrome Mouse Models by Modulating the Unfolded Protein Response
Dr. Elsa Pittaras
Researcher
Stanford University
Effect of a tryptophan enriched diet on mood, cognition, sleep and their associated neurotransmitters/hormones in a mouse model of Down Syndrome.
Prof. Katie Hsiao
Assistant Professor
Children's National Hospital
Altered motor coordination and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21
Dr. Emily Schworer
Postdoc
University of Wisconsin-Madison
Plasma glial fibrillary acidic protein in adults with Down syndrome: Associations with amyloid positivity and cognitive performance
Ms. Samantha Baker
Clinical Research Coordinator
The Linda Crnic Institute For Down Syndrome
DS-Connect®: The Down Syndrome Registry: Linking Community, Data and Discovery
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