S7. Amyloid-lowering Immunotherapies for Down Syndrome-related Alzheimer’s disease: Neuropathological Insights and Vascular Safety in Clinical Trials
Tracks
Room 1 | Capitol Ballroom
| Thursday, June 18, 2026 |
| 9:30 - 11:30 |
| Room 1 | Capitol Ballroom |
Speaker
Dr. Isabel Barroeta
Faculty Neurologist
HOSPITAL DE LA SANTA CREU I SANT PAU (Centre CERCA)
Introduction
9:30 - 9:35
Dr. Lisi Flores Aguilar
Postdoctoral Scholar
University of California, Irvine
Neuropathology of the blood-brain barrier across the AD continuum in Down syndrome: implications for amyloid lowering therapies.
9:40 - 10:00
Donna M Wilcock
Biomarkers and vascular burden in DS: tools to inform safety and clinical trial readiness.
10:00 - 10:20
Mrs Lucia Maure Blesa
Md, Phd Candidate
Unitat Alzheimer Down, Hospital de la Santa Creu i Sant Pau
Clinical perspectives and case reports: understanding safety and indications of anti-amyloid therapies in DS.
10:20 - 10:40
Prof. Michael Rafii
Professor
Keck School Of Medicine Of USC
Amyloid-immunotherapy clinical trials in Down syndrome: design, safety considerations, and lessons for the field.
10:40 - 11:00
Dr. Isabel Barroeta
Faculty Neurologist
HOSPITAL DE LA SANTA CREU I SANT PAU (Centre CERCA)
Panel discussion and Q&A
11:00 - 11:30
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