S3 Program (Endocrinology and Metabolism)
Organizers:
Gema Frühbeck - Dept. of Endocrinology & Nutrition, Clinica Universidad de Navarra, Pamplona
Maria Paula Macedo - ESCI Council – NOVA Universidad Medical School, Lisbon, Portugal
Patrícia Afonso-Mendes - ESCI Young Research Council – Centro Hospitalar e Universitário de Coimbra Portugal
Wednesday June 5, 2024
13:30h – 15:00h
SYMPOSIUM 3.1 | REVISITING THE BEYOND BMI PARADIGM
Chairpersons: Gema Frühbeck & Jean Michel Oppert
Redifining and reframing obesity
Gema Frühbeck. Pamplona, Spain
Morphofunctional assessment for obesity characterization – Theoretical framework
José Manuel García Almeida. Málaga, Spain
Morphofunctional assessment for obesity characterization – Practicalities
Isabel Vegas. Málaga, Spain
Abstract 1: BMI-based obesity classification misses children and adolescents with raised cardiometabolic risk due to elevated adiposity
Javier Gómez-Ambrosi, University of Navarra, Spain
Abstract 2: Cardiometabolic risk stratification using a novel obesity phenotyping system based on body adiposity and waist circumference
Javier Gómez-Ambrosi, University of Navarra, Pamplona, Spain
Abstract 3: Chemerin, Adiponectin, and Detrimental Lipid Species: implications for sex-specific metabolic dysregulation. A cluster analysis
Rita Patarrão. Nova Medical School, Lisbon, Portugal
15:00h – 15:30h
COFFEE BREAK
15:30h – 17:00h
SYMPOSIUM 3.2 | INSULIN DYNAMICS IN OBESITY
Chairpersons: Didac Mauricio & Paulo Matafome
Understanding the obesity-insulin connection
Sonia Najjar. Ohio, United States
Phenotyping obesity through the lens of insulin mechanisms
Paula Macedo. Lisboa, Portugal
Abstract 1: Conditional deletion of CEACAM1 causes hepatic stellate cell activation
Hilde Ghadieh. University of Balamand, Lebanon
Abstract 2: The impact of type 2 diabetes on gene expression of fructose metabolism enzymes in human adipose tissue
Ana Reis-Costa. University of Coimbra, Coimbra, Portugal
Abstract 3: Unraveling the Link between ICAM-1 and Inflammatory/Atherogenic Factors in Cord Blood Plasma from Gestational Diabetes Pregnancies
Carolina Tocantins. Medical University of Graz, Graz, Austria
17:00h – 17:30h
OPENING CEREMONY
17:30h-18-30h
OPENING LECTURE
Epigenetics in Health and Disease: From Knowledge to Applications
Manel Esteller. Barcelona, Spain
18:30h - 19:30h
SATELLITE SYMPOSIUM FICYE | MEDITERRANEAN DIET, BEER AND HEALTH
**The Forum for Beer and Lifestyle Research (FICYE) is an entity that promotes research on beer and its relationship with lifestyle**
Ageing and nutrition: delaying chronological age by improving physiological age
Lina Badimon. Molecular Pathology and Therapeutics Department, IR-Hospital de Sant Pau, Barcelona, Spain
Beer, nutrition and immunity
Ascensión Marcos. Malaga Biomedical Research Institute and Nanomedicine Platform (IBIMA)
Gut microbiota, beer and diet
Isabel Moreno. Malaga Biomedical Research Institute and Nanomedicine Platform (IBIMA)
19:30-21.00h
BEER TASTING AND CHAMPIONS LEAGUE UNIVERSITIES
Thursday June 6, 2024
8:15h – 9:00h
PAS GRAS OUTREACH ACTIVITY
9:00h – 10:30h
SYMPOSIUM 3.3 | PHENOTYPING THE OBESITIES
Chairpersons: Javier Gómez-Ambrosi & Paolo Sbraccia
Obesity related comorbidities
Cyrielle Caussy. Lyon, France
Sarcopenic obesity
Alfonso J. Cruz Jentoft. Madrid, Spain
Abstract 1: Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity
Laura Salmón-Gómez. Clínica Universidad de Navarra, Pamplona, Spain
Abstract 2: Defective Olfactomedin 2 functionally connects adipocyte phenotype severity to obesity
Aina Lluch. Institut d’Investigació Biomédica de Girona (IDIBGI), Girona, Spain
Abstract 3: Decreased expression of the NLRP6 inflammasome in jejunum is associated with inflammation in obesity and type 2 diabetes
Victoria Catalán. Clínica Universidad de Navarra, Pamplona, Spain
10:30h – 11:00h
COFFEE BREAK
11:00h – 12:30h
SYMPOSIUM 3.4 | OBESITY'S TOLL ON LIVER HEALTH
Chairpersons: Paula Macedo & Cyrielle Caussy
Global burden of MASLD and risk stratification using non-invasive tests
Zobair Younossi. Northern Virginia, United States
Multifactorial approach to MASLD in obesity and its related metabolic conditions
Didac Mauricio. Barcelona, Spain
Abstract 1: Circulating levels of FNDC4 are reduced in patients with metabolic dysfunction-associated steatotic liver disease
Gabriela Neira. Clínica Universidad de Navarra, Pamplona, Spain
Abstract 2: Protective role of uroguanylin against hepatic steatosis, mitochondrial dysfunction and fibrosis in metabolic dysfunction-associated steatotic liver disease
Amaia Rodríguez. Clínica Universidad de Navarra, Pamplona, Spain
Abstract 3: Beyond the Liver: Impact of high-fat-induced MASLD in the lipidomic profiles of mice extrahepatic tissues
João Silva. University of Coimbra, Coimbra, Portugal
12:30h -13:30h
POSTER SESSION
13:30h - 14:30h
LUNCH
14:30h - 16:00h
SYMPOSIUM 3.5 | PILLARS OF OBESITY MANAGEMENT
Chairpersons: José Manuel García Almeida & Dimitri Kiortsis
Nutritional approaches for weight loss and maintenance
Patricia Yárnoz Esquíroz. Pamplona, Spain
Physical activity and exercise for weight loss and maintenance
Jean Michel Oppert. Paris, France
Abstract 1: The neuropeptide Y/melanocortin system in adipose tissue is regulated by ghrelin and leptin and is impaired in insulin-resistant patients
Daniela Rosendo-Silva. Institute for Clinical and Biomedical Research (iCBR), Coimbra, Portugal
Abstract 2: Disruption of neuroendocrine mechanisms of energy balance in hypothalamus and brown adipose tissue in overfed rats exposed to maternal glycation
Diana Sousa. Institute for Clinical and Biomedical Research (iCBR), Coimbra, Portugal
Abstract 3: N-Acetylaspartylglutamic acid (NAAG): a novel hippocampal compensatory mechanism against glucose intolerance in obesity?
Beatriz Caramelo. Institute for Clinical and Biomedical Research (iCBR), Coimbra, Portugal
Friday, June 7 2024
9:00h – 10:30h
SYMPOSIUM 3.6 | THERAPEUTIC APPROACHES
Chairpersons: Alfonso J. Cruz Jentoft & Sonia Najjar
Obesity pharmacotherapy: Where we are
Dimitri Kiortsis. Ioannina, Greece
Obesity pharmacotherapy: where we are going
Paolo Sbraccia. Rome, Italy
Abstract 1: Association between cerebrospinal fluid fatty acid profile, neuroimaging markers of hypothalamic inflammation, and weight loss after bariatric surgery
Gemma Chiva-Blanch. Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Abstract 2: Comparing the effects of carotid sinus nerve denervation versus estradiol on metabolic parameters in ovariectomized hypercaloric fed female rats
Marcos Vinicius Fernandes. Universidade NOVA de Lisboa, Lisboa, Portugal
Abstract 3: Gene therapy-mediated expression of CPT1AM in brown adipose tissue mitigates obesity and insulin resistance in mice
Marijana Todorcevic.
10:30h – 11:00h
COFFEE BREAK
11:00h – 12:30h
SYMPOSIUM 3.7 | FUTURE PERSPECTIVES. ROUND TABLE
Chairperson: Paula Macedo & Gema Frühbeck
Speakers:
Sonia Najjar. Ohio, United States
Cyrielle Caussy. Lyon, France
Paulo Matafome. Coimbra, Portugal
Carolina Perdomo. Pamplona, Spain
Topics to be discussed:
- Role of the exposome in the development of the obesity pandemic
- Obesity paradox
- Artificial intelligence and social media role in obesity management
- Place of bariatric surgery in obesity treatment
- Investigation in the obesity field
Abstract 1: Gene expression levels of IL-1β are increased in visceral adipose tissue from patients with obesity and associated with inflammation
Gabriela Neira. Clínica Universidad de Navarra, Pamplona, Spain
Abstract 2: Remodeling of nuclear architecture and chromatin epigenetics during adipocyte differentiation and hypertrophy: a super-resolution microscopy-based approach
Lama Zeaiter. University of Genoa, Genova, Italy
Abstract 3: Uroguanylin prevents the activation of Hippo-YAP pathway induced by palmitate in HepG2 hepatocytes: potential role in the MASLD-associated hepatocellular carcinoma
Maite Losarcos. Clínica Universidad de Navarra, Pamplona, Spain
12:30h - 14:00h
LUNCH
14:00h - 14:30h
EDITOR IN CHIEF EJCI / AWARD BEST ARTICLES EJC
14:30h - 15:30h
ESCI AWARDS
15:30h - 16:30h
ALBERT STRUYVENBERG MEDAL TO PROF. VALENTIN FUSTER AND LECTURE AWARD
16:30h - 17:00h
CLOSING