Organizers:

Gema Frühbeck - Dept. of Endocrinology & Nutrition, Clinica Universidad de Navarra, Pamplona
Maria Paula Macedo - ESCI Council – NOVA Universidad Medical School, Lisbon, Portugal
Patrícia Afonso-Mendes - ESCI Young Research Council – Centro Hospitalar e Universitário de Coimbra Portugal 

Wednesday June 5, 2024

13:30h – 15:00h

SYMPOSIUM 3.1 | REVISITING THE BEYOND BMI PARADIGM
Chairpersons: Gema Frühbeck (Pamplona, Spain) & Jean Michel Oppert (Paris, France)

Redefining and reframing obesity
Gema Frühbeck. Clínica Universidad de Navarra. Pamplona, Spain           

Morphofunctional assessment for obesity characterization – Theoretical framework
José Manuel García Almeida. Hospital Virgen de la Victoria. Málaga, Spain 

Morphofunctional assessment for obesity characterization – Practicalities 
Isabel Vegas. Hospital Virgen de la Victoria. Málaga, Spain  

Abstract 1: BMI-based obesity classification misses children and adolescents with raised cardiometabolic risk due to elevated adiposity 
Javier Gómez-Ambrosi, University of Navarra, Spain

Abstract 2: Cardiometabolic risk stratification using a novel obesity phenotyping system based on body adiposity and waist circumference 
Javier Gómez-Ambrosi, University of Navarra, Pamplona, Spain

Abstract 3: Chemerin, Adiponectin, and Detrimental Lipid Species: implications for sex-specific metabolic dysregulation. A cluster analysis
Rita Patarrão. Nova Medical School, Lisbon, Portugal

15:00h – 15:30h

COFFEE BREAK

15:30h – 17:00h

SYMPOSIUM 3.2 | INSULIN DYNAMICS IN OBESITY
Chairpersons: Paulo Matafome (Coimbra, Portugal)

Understanding the obesity-insulin connection
Sonia Najjar. Ohio University. Ohio,  United States 

Phenotyping obesity through the lens of insulin mechanisms 
Paula Macedo. Nova Medical School. Lisboa, Portugal 

Abstract 1: Blocking insulin action in the carotid body: could this be a new paradigm to treat obesity and type 2 diabetes?
Silvia Conde. Nova Medical School. Lisboa, Portugal

Abstract 2: The impact of type 2 diabetes on gene expression of fructose metabolism enzymes in human adipose tissue
Ana Reis-Costa. University of Coimbra, Coimbra, Portugal

Abstract 3: Unraveling the Link between ICAM-1 and Inflammatory/Atherogenic Factors in Cord Blood Plasma from Gestational Diabetes Pregnancies
Carolina Tocantins. Medical University of Graz, Graz, Austria

17:00h – 17:30h

OPENING CEREMONY

17:30h-18-30h

OPENING LECTURE

Epigenetics in Health and Disease: From Knowledge to Applications
Manel Esteller. Barcelona, Spain

18:30h - 19:30h

SATELLITE SYMPOSIUM FICYE | MEDITERRANEAN DIET, BEER AND HEALTH

Chairperson: Lina Badimon (Barcelona, Spain)

**The Forum for Beer and Lifestyle Research (FICYE) is an entity that promotes research on beer and its relationship with lifestyle**

Ageing and nutrition: delaying chronological age by improving physiological age

Lina Badimon. Molecular Pathology and Therapeutics Department, IR-Hospital de Sant Pau, Barcelona, Spain

Beer, nutrition and immunity

Ascensión Marcos. Malaga Biomedical Research Institute and Nanomedicine Platform (IBIMA)

Gut microbiota, beer and diet

Isabel Moreno. Malaga Biomedical Research Institute and Nanomedicine Platform (IBIMA)

19:30-21.00h

BEER TASTING AND CHAMPIONS LEAGUE UNIVERSITIES

Thursday June 6, 2024 

8:15h – 9:00h

PAS GRAS OUTREACH ACTIVITY 

9:00h – 10:30h

SYMPOSIUM 3.3 | PHENOTYPING THE OBESITIES
Chairpersons: Javier Gómez-Ambrosi (Pamplona, Spain) & Paolo Sbraccia (Rome, Italy)

Obesity related comorbidities
Cyrielle Caussy. Hospices Civils de Lyon. Lyon, France 
 
Sarcopenic obesity
Alfonso J. Cruz Jentoft. Hospital Universitario Ramón y Cajal. Madrid, Spain 

Abstract 1: Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity 
Laura Salmón-Gómez. Clínica Universidad de Navarra, Pamplona, Spain

Abstract 2: Defective Olfactomedin 2 functionally connects adipocyte phenotype severity to obesity
Aina Lluch. Institut d’Investigació Biomédica de Girona (IDIBGI), Girona, Spain

Abstract 3: Decreased expression of the NLRP6 inflammasome in jejunum is associated with inflammation in obesity and type 2 diabetes
Victoria Catalán. Clínica Universidad de Navarra, Pamplona, Spain

10:30h – 11:00h

COFFEE BREAK

11:00h – 12:30h

SYMPOSIUM 3.4 | OBESITY'S TOLL ON LIVER HEALTH
Chairpersons: Paula Macedo (Lisbon, Portugal) & Cyrielle Caussy (Lyon, France)

Global burden of MASLD and risk stratification using non-invasive tests **Pre-Recorded**
Zobair Younossi. Inova Health System. Northern Virginia, United States 

Multifactorial approach to MASLD in obesity and its related metabolic conditions
Didac Mauricio. Hospital de la Santa Creu i Sant Pau. Barcelona, Spain  

Abstract 1: Circulating levels of FNDC4 are reduced in patients with metabolic dysfunction-associated steatotic liver disease 
Gabriela Neira. Clínica Universidad de Navarra, Pamplona, Spain

Abstract 2: Protective role of uroguanylin against hepatic steatosis, mitochondrial dysfunction and fibrosis in metabolic dysfunction-associated steatotic liver disease 
Amaia Rodríguez. Clínica Universidad de Navarra, Pamplona, Spain

Abstract 3: Beyond the Liver: Impact of high-fat-induced MASLD in the lipidomic profiles of mice extrahepatic tissues
João Silva. University of Coimbra, Coimbra, Portugal

12:30h -13:30h

POSTER SESSION

13:30h - 14:30h

LUNCH

14:30h - 16:00h

SYMPOSIUM 3.5 | PILLARS OF OBESITY MANAGEMENT
Chairpersons: Amaia Rodríguez (Pamplona, Spain) & Gabriela Neira (Pamplona, Spain)

Nutritional approaches for weight loss and maintenance
Patricia Yárnoz Esquíroz. Clínica Universidad de Navarra. Pamplona, Spain 

Physical activity and exercise for weight loss and maintenance 
Jean Michel Oppert. Sorbonne Université. Paris, France 

Abstract 1: The neuropeptide Y/melanocortin system in adipose tissue is regulated by ghrelin and leptin and is impaired in insulin-resistant patients 
Daniela Rosendo-Silva. Institute for Clinical and Biomedical Research (iCBR), Coimbra, Portugal

Abstract 2: Disruption of neuroendocrine mechanisms of energy balance in hypothalamus and brown adipose tissue in overfed rats exposed to maternal glycation 
Diana Sousa. Institute for Clinical and Biomedical Research (iCBR), Coimbra, Portugal

Abstract 3: N-Acetylaspartylglutamic acid (NAAG): a novel hippocampal compensatory mechanism against glucose intolerance in obesity? 
Beatriz Caramelo. Institute for Clinical and Biomedical Research (iCBR), Coimbra, Portugal

Friday, June 7 2024 

9:00h – 10:30h

SYMPOSIUM 3.6 | THERAPEUTIC APPROACHES
Chairpersons: Alfonso J.  Jentoft (Madrid, Spain) & Sonia Najjar (Ohio, United States)

Obesity pharmacotherapy: Where we are 
Dimitri Kiortsis. University of Ioannina. Ioannina, Greece 

Obesity pharmacotherapy: where we are going 
Paolo Sbraccia. University of Rome. Rome, Italy 

Abstract 1: Association between cerebrospinal fluid fatty acid profile, neuroimaging markers of hypothalamic inflammation, and weight loss after bariatric surgery
Gemma Chiva-Blanch. Instituto de Salud Carlos III (ISCIII), Madrid, Spain

Abstract 2: Comparing the effects of carotid sinus nerve denervation versus estradiol on metabolic parameters in ovariectomized hypercaloric fed female rats 
Joana Sacramento. Universidade NOVA de Lisboa, Lisboa, Portugal

Abstract 3: Gene therapy-mediated expression of CPT1AM in brown adipose tissue mitigates obesity and insulin resistance in mice
Marijana Todorcevic. University of Barcelona. Barcelona, Spain

10:30h – 11:00h

COFFEE BREAK

11:00h – 12:30h

SYMPOSIUM 3.7 | FUTURE PERSPECTIVES. ROUND TABLE
Chairperson: Paula Macedo (Lisbon, Portugal) & Gema Frühbeck (Pamplona, Spain)

          Speakers:
          Sonia Najjar. Ohio, United States 
          Paulo Matafome. Coimbra, Portugal
          Carolina Perdomo. Pamplona, Spain

          Topics to be discussed:
            - Role of the exposome in the development of the obesity pandemic
            - Obesity paradox
            - Artificial intelligence and social media role in obesity management
            - Place of bariatric surgery in obesity treatment
            - Investigation in the obesity field 

Abstract 1: Gene expression levels of IL-1β are increased in visceral adipose tissue from patients with obesity and associated with inflammation
Gabriela Neira. Clínica Universidad de Navarra, Pamplona, Spain

Abstract 2: Uroguanylin prevents the activation of Hippo-YAP pathway induced by palmitate in HepG2 hepatocytes: potential role in the MASLD-associated hepatocellular carcinoma
Maite Losarcos. Clínica Universidad de Navarra, Pamplona, Spain

12:30h - 14:00h

LUNCH

14:00h - 14:30h

EDITOR IN CHIEF EJCI / AWARD BEST ARTICLES EJC

14:30h - 15:30h

ESCI AWARDS

15:30h - 16:30h

ALBERT STRUYVENBERG MEDAL TO PROF. VALENTIN FUSTER AND LECTURE AWARD

16:30h - 17:00h

CLOSING